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Boswellia and Curcumin
Prove Effective for Osteoarthritis of the Knee

by L. Stephen Coles M.D.,Ph.D.


If you have osteoarthritis, you know how difficult it can be to find pain relief that works without adverse effects to your stomach, liver and kidneys. The drugs that many people use over the long term can be dangerous, no doubt about it. Nonsteroidal inflammatory drugs (NSAIDs) like ibuprofen, aspirin, naproxen, celecoxib and others have safety and tolerability issues that are well known. On top of that, they are often ineffective.

The time is right for a different, all-natural approach that is both safer and more effective!

Using a combination of two botanical ingredients that have been well known to ayurvedic medicine and naturally improving their efficacy, researchers have moved natural remedies to the forefront of arthritis care.

Recently, a unique combination of bioavailable curcumin and boswellia was judged to be superior to the prescription arthritis drug celecoxib (the generic of the brand name Celebrex) in a clinical study of osteoarthritis.

These are powerful botanical ingredients: the curcumin extract (from turmeric) has up to 10 times the absorption of standard curcumin extracts, and the boswellia extract has reduced levels of beta-boswellic acids, which can otherwise cause inflammation and pain.

Dr. R. Kizhakkedath, orthopedic physician and lead author of the study, chose these particular ingredients for a reason. “We chose to examine BCM-95 because it has superior bioavailability over plain curcumin. The BosPure boswellia has a standardization of 10 percent or more acetyl-11-keto-beta-boswellic acid (AKBA) and very low beta boswellic acid (<5 percent). This standardization greatly improves the anti-inflammatory activity. In combination, these herbs complement one another and are highly effective.”

Individuals in the 12-week study were randomized into two groups. One group received 100 mg of celecoxib twice daily, and the second group received a 500 mg blend of the highly absorbable curcumin and boswellia extract twice daily.

When it came to relieving pain, 64 percent of those taking the herbal ingredients improved. Among those taking the drug, 29 percent reported improvement.

One-way analysis of variance (ANOVA) was used to analyze safety and efficacy data to determine statistically significant differences between treatment groups or between time points within groups. The test was used to analyze data on joint pain and walking distance measurements, joint line tenderness, crepitus, range of motion and joint swelling. Other measures were liver and kidney function tests, white blood cell counts and differentials, sedimentation rates and vital signs at each visit.

At the end of the study, 93 percent of the herbal-treated subjects could walk more than 1,000 meters versus 86 percent in the drug group. Ninety-three percent of the herbal group reported improvement in or elimination of pain versus 79 percent of the drug group. Both groups had significant improvements in range of motion, but there were no statistically significant differences between the herbal versus drug group on this measurement. There were no serious adverse events in the study.

The authors of the study concluded, “This botanical combination at 500 mg twice daily was better than celecoxib 100 mg twice daily in pain, walking distance and joint line tenderness scores. It was equally effective as celecoxib in alleviating crepitus and range of joint movements.” That alone is impressive, but they also added, “Efficacy and tolerability of the herbal combination used in the current study was shown to be superior to those of celecoxib (NSAID) for treating active osteoarthritis.”

If you’re tired of conventional approaches to dealing with osteoarthritis, maybe it’s time to consider these amazing, effective ingredients and rediscover mobility without the risks. I recommend curcumin formulas from EuroPharma. For more information, visit www.europharmausa.com


Dr. Coles is a visiting scholar at UCLA and is the world’s leading researcher into supercentenarians (the longest-lived people on earth).


References

Antony B, Kizhakkedath R, Benny M, Kuruvilla B. Clinical evaluation of an herbal formulation in the management of knee osteoarthritis. Poster presented at the Osteoarthritis Research Symposium Internationale (OARSI) Annual World Congress on Osteoarthritis, September 15-18, 2011. San Diego, CA.

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