Prove Effective for Osteoarthritis of the Knee
by L. Stephen Coles M.D.,Ph.D.
If you have osteoarthritis, you know how
difficult it can be to find pain relief that
works without adverse effects to your
stomach, liver and kidneys. The drugs that
many people use over the long term can be
dangerous, no doubt about it. Nonsteroidal
inflammatory drugs (NSAIDs) like ibuprofen,
aspirin, naproxen, celecoxib and others have
safety and tolerability issues that are well known.
On top of that, they are often ineffective.
The time is right for a different, all-natural
approach that is both safer and more effective!
Using a combination of two botanical ingredients
that have been well known to ayurvedic
medicine and naturally improving their efficacy,
researchers have moved natural remedies to
the forefront of arthritis care.
Recently, a unique combination of bioavailable
curcumin and boswellia was judged to be
superior to the prescription arthritis drug celecoxib
(the generic of the brand name Celebrex)
in a clinical study of osteoarthritis.
These are powerful botanical ingredients:
the curcumin extract (from turmeric) has up to
10 times the absorption of standard curcumin
extracts, and the boswellia extract has reduced
levels of beta-boswellic acids, which can otherwise
cause inflammation and pain.
Dr. R. Kizhakkedath, orthopedic physician
and lead author of the study, chose these particular
ingredients for a reason. “We chose to
examine BCM-95 because it has superior
bioavailability over plain curcumin. The
BosPure boswellia has a standardization of 10
percent or more acetyl-11-keto-beta-boswellic
acid (AKBA) and very low beta boswellic acid
(<5 percent). This standardization greatly
improves the anti-inflammatory activity. In
combination, these herbs complement one
another and are highly effective.”
Individuals in the 12-week study were randomized
into two groups. One group received 100 mg
of celecoxib twice daily, and the second group
received a 500 mg blend of the highly absorbable
curcumin and boswellia extract twice daily.
When it came to relieving pain, 64 percent of
those taking the herbal ingredients improved.
Among those taking the drug, 29 percent reported
One-way analysis of variance (ANOVA) was
used to analyze safety and efficacy data to determine
statistically significant differences between
treatment groups or between time points within
groups. The test was used to analyze data on joint
pain and walking distance measurements, joint line
tenderness, crepitus, range of motion and joint
swelling. Other measures were liver and kidney function
tests, white blood cell counts and differentials,
sedimentation rates and vital signs at each visit.
At the end of the study, 93 percent of the
herbal-treated subjects could walk more than
1,000 meters versus 86 percent in the drug group.
Ninety-three percent of the herbal group reported
improvement in or elimination of pain versus 79
percent of the drug group. Both groups had significant
improvements in range of motion, but
there were no statistically significant differences
between the herbal versus drug group on this
measurement. There were no serious adverse
events in the study.
The authors of the study concluded, “This
botanical combination at 500 mg twice daily was
better than celecoxib 100 mg twice daily in pain,
walking distance and joint line tenderness scores.
It was equally effective as celecoxib in alleviating
crepitus and range of joint movements.” That
alone is impressive, but they also added, “Efficacy
and tolerability of the herbal combination used in
the current study was shown to be superior to
those of celecoxib (NSAID) for treating active
If you’re tired of conventional approaches to
dealing with osteoarthritis, maybe it’s time to consider
these amazing, effective ingredients and
rediscover mobility without the risks. I recommend curcumin formulas from EuroPharma. For more information, visit www.europharmausa.com
Dr. Coles is a
at UCLA and is
the world’s leading researcher into
supercentenarians (the longest-lived
people on earth).
Antony B, Kizhakkedath R, Benny M, Kuruvilla B. Clinical evaluation of an herbal
formulation in the management of knee osteoarthritis. Poster presented at the
Osteoarthritis Research Symposium Internationale (OARSI) Annual World Congress
on Osteoarthritis, September 15-18, 2011. San Diego, CA.
Copyright. All rights reserved.